研究队伍
 
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研究队伍

姓 名:
  张键
性 别:
  女
职 称:
  研究员
学 历:
  博士
通讯地址:
  深圳市南山区西丽深圳大学城学苑大道1068号
电 话:
  0755-86392290
传 真:
 
电子邮件:
  Jian.zhang@siat.ac.cn
个人主页:
  http://sourcedb.siat.cas.cn/zw/zjrc/201103/t20110316_3086323.html

简介:

中国科学院动物研究所生殖生物学国家重点实验室获得博士学位(1999-2003),美国斯坦福大学妇产科系博士后(2003-2008),ELIXIR/美国斯坦福大学病理系Scientist(2008-2010)。2011年中国科学院“百人计划”,2012年深圳市杰出青年基金获得者,2014年深圳市“孔雀计划”海外高层次B类人才。长期从事天然内源性多肽的开发及其在代谢疾病和生殖疾病中的研究,发现并成功分离纯化两个多肽激素:Obestatin和Neuronostatin,申请5项美国PCT专利,9项中国专利,已授权专利1项,在国内外学术刊物发表SCI收录论文达40篇,包括Science, JBC, Molecular Endocrinology,Scientific Reports,Plos One和Molecular Human Reproduction等,总影响力121,引用次数1100多次,为多家杂志审稿人。现为美国内分泌协会,糖尿病协会会员,中国生殖生物学分会理事。获得中国科学院研究生创新津贴(2002年),中国科学院院长优秀奖(2003年),德国Weimar会议最佳poster展示奖(2002年)。


研究方向:

1)筛选天然内源性活性多肽,及其受体激动剂/拮抗剂,制备多肽及其受体的抗体; 

2)研究多肽及其受体在以肥胖为主的代谢疾病及内分泌代谢相关生殖疾病中的作用。 

代谢疾病包括:肥胖症,脂肪肝,糖尿病,和骨质疏松。 

生殖疾病包括:卵巢早衰,多囊卵巢综合征,妊娠糖尿病、子宫内膜癌,卵巢癌/乳腺癌和复发性流产。 


专家类别:

职务:

社会任职:

获奖及荣誉:
中国科学院研究生创新津贴(2002年)

中国科学院院长优秀奖(2003年)

德国Weimar会议最佳poster展示奖(2002年)

代表论著:

 

1. LingweiWang,JieLi,Jian Zhang, Qi He,XuanwenWeng,Minjie Guan, Chen qiu*.Inhibition of TRPC3 Downregulates Airway Hyperresponsiveness, Remodeling of OVA-sensitized mouse.Biochemicaland Biophysical Research Communications

    .Volume 484, Issue 1, 26 February 2017, Pages 209-217(IF2.297)

2. Le AW *,Shan LL,DaiXY,XiaoTH,LiXR,WangZH,Zhang J*(共同通讯作者),Chen XY*.PI3K, AKT and P-AKT levels in thin endometrium.GenetMol Res.2016, 15(1),DOI: 10.4238/gmr.15017184(IF0.764)

3. 刘华东,熊玮,刘启云,李江华,吴美善,张键,董少红. 人趋化因子受体1促进小鼠血管平滑肌细胞增殖的机制研究.中华心血管病杂志,2016, 44(7),605-609页(IF1.626)

4. JianLi,QiangXu,BinTeng,ChenYua,JianLi,LiangSong,Yu-xiaoLai,JianZhang,WeiZheng ,Pei-Gen Ren.Investigation of angiogenesis in bioactive 3-dimensional poly (d,l-lactide-co-glycolide) /nano- hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect,ActaBiomaterialia,2016, 42:389-399(IF6.008)

5. 肖仲琳,杨青,张键,范秀军.子痫前期动物模型的研究进展.生物化学与生物物理进展,2016,43(6):563-569(IF0.324)

6. Ya-Li Yang,Li-RongRen,Li-FengSun,ChenHuang,Tian-Xia Xiao,Bao-BeiWang,JieChen,BrianA.Zabel,PeigenRen,JianV.Zhang(通讯作者).The role of GPR1 signaling in mice corpus luteum.Journal of Endocrinology,2016 ,230(1):55-65(IF4.498)

7. Chen Huang, Miaomiao Wang; lirongRen,Liang Xiang, JieChen,MengxiaLi,Tianxia Xiao,PeigenRen,LikuanXiong,JianV.Zhang(通讯作者).CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet.Biochemical and Biophysical Research Communications,2016,473(2):435-441(IF2.297)

8. JianLi,BinTeng,Ri-QiangLin,ChangShe,Zhen-Yu Yao,JianZhang,LiangSong,Pei-Gen Ren.Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study.IARJSET,DOI 10.17148/IARJSET.2016.3435 (IF5.332)

9. MiTang,ChenHuang,Yu-FeiWang,Pei-Gen Ren,Tian-Xia Xiao,Bao-BeiWang,Yan-Fei Pan, Benjamin K. Tsang, Brian A Zabel, Bao-HuaMa, Hui-Ying Zhao, Jian V Zhang(通讯作者).CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone. Scientific Reports,2016 6:21328 DOI: 10.1038/srep21328(IF5.578)

10. 熊玮,董少红,张键,李江华,廖碧红,庞新利,罗林杰.趋化素促进小鼠血管平滑肌细胞增殖的实验研究,临床心血管病杂志,2016,01期,66-69页

11. ChengzhiGuo,JianLi,ChangShe,XiangzhiShao,BinTeng,JingFeng,Jian V. Zhang(共同通讯作者),Pei-Gen Ren.Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro,Journal of Biomedical Materials Research B:Applied Biomaterials , 2015, 104(5):923-931(IF2.759)

12. Chen Qiu#,Jian Zhang#(共同一作), Meiping Su, Xiujun Fan.Nuclear factor-κB mediates the phenotype switching of airway smooth muscle cells in a murine asthma model. Int J ClinExpPathol.2015,8(10):12115-12128 (IF1.891)

13. ZHANGQing-Qing, FANXiu-Jun*,ZHANGJian(通讯作者).The Role of AdipokineChemerin in Pregnancy Complications.Progress in Biochemistry and Biophysics,2015, 42(10): 962-968(IF0.324)

14. 熊玮,董少红,张键,李江华,廖碧红,庞新利,罗林杰.趋化素通过上调磷酸化JNK促进小鼠血管平滑肌细胞的增殖,中国病理生理杂志,2015,12期, 2282-2286页

15. 熊玮,董少红,张键,李江华,吴美善,廖碧红,庞新利,罗林杰.Chn1基因缺陷性小鼠血管平滑肌细胞株的构建和鉴定,广东医学,2015年16期,2495-2498页

16. 孙立峰,杨雅莉,张键(通讯作者).肥胖引起的氧化应激及其对两性生殖的影响,公共卫生与预防医学,公共卫生与预防医学 2015年第26 卷第4期,71-73页

17. 田小飞,马玮娟,张键(通讯作者).脂肪因子Chemerin与非酒精性脂肪肝病的关系,公共卫生与预防医学, 2015, 26(2):75-77页

18. 田小飞,马玮娟,方光光,肖天霞,陈杰,张键(通讯作者).The Effects of Experimental Mice Adipose Accumulation by Targeting GPR1 Pathway,生物化学与生物物理进展,2015,42(5):457-467(IF0.324)

19. 陈曾,徐展望,向亮,张鹏,张键(通讯作者). 脂肪因子chemerin与骨质疏松症的关系展望,中国骨质疏松杂志,2014年12月第20卷第12期,1506-1510页

20. Graham KL, Zhang JV, Lewén S, Burke TM, Dang T, Zoudilova M, Sobel RA, Butcher EC, Zabel BA. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease. PLOS ONE,2014 Dec 1;9(12):e112925(IF:3.534)

21. Pandey V, Wu ZS, Zhang M, Li R, Zhang J, Zhu T*, Lobie PE*. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma. Breast Cancer Res.2014 Sep 30;16(5):429.doi: 10.1186/s13058-014-0429-3(IF5.490)

22. Li L, Huang C, Zhang X, Wang J, Ma P, Liu Y, Xiao T, Zabel BA, Zhang J(通讯作者). Chemerin-derived peptide C-20 suppressed gonadal steroidogenesis. American Journal of Reproductive Immunology. 2014 Mar;71(3):265-277(IF:3.317)

23. 黄庆生,肖天霞,张键(通讯作者),魏彦杰. 内皮素-1 在均匀流中构象改变的分子动力学模拟.集成技术,2014年3月第3卷第2期,17-26页

24. Li L, Ma P, Huang C, Liu Y, Zhang Y, Gao C, Xiao T, Ren PG, Zabel BA, Zhang  JV(通讯作者). Expression of chemerin and its receptors in rat testes and its actions on  testosterone secretion. J Endocrinol. 2013, 220(2):155-163 (IF: 4.058 )

25. Lei Li, Ping Ma, Yongjun Liu, Chen Huang, Wai-sum O, Fai Tang, Jian V Zhang(通讯作者).Intermedin Attenuates LPS-induced Inflammation in the Rat Testis. PLOS ONE, 2013; 8(6): e65278. doi: 10.1371 (IF: 3.730)

26. Zhang JV*(通讯作者), Li L, Huang Q, Ren PG. Obestatin receptor in energy homeostasis and obesity pathogenesis. ProgMolBiolTransl Sci. 2013,114:89-107(IF: 2.3)

27. Zhao L, Purandare B, Zhang J, Hantash BM. β2-Microglobulin-free HLA-G activates natural killer cells by increasing cytotoxicity and proinflammatory  cytokine production. Hum Immunol. 2013,74(4):417-424(IF: 2.298)  

28. Samson WK#, Zhang JV#(共同一作), Avsian-Kretchmer O, Cui K, Yosten GL, Klein C, Lyu RM, Wang YX, Chen XQ, Yang J, Price CJ, Hoyda TD, Ferguson AV, Yuan XB, Chang JK, Hsueh AJ. Neuronostatin encoded by the somatostatin gene induces gene expression in brain/gut tissues, regulates metabolic functions, and modulates neuronal migration. J Biol Chem. 2008,283(46):31949-31959(IF;5.520)

29.  Zhang JV, Jahr H, Luo CW, Klein C, Van Kolen K, VerDonck L, De A, Baart E, Li J, Moechars D, Hsueh AJ. Obestatin induction of early response gene expression in gastrointestinal and adipose tissues and the mediatory role of GPR39. MolEndocrinol. 2008, 22(6):1464-1475(IF:5.389)

30. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Response to comments: “Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake”.Science. 2007,315:766d-766d (IF:26.372)

31. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science. 2005,310(5750):996-999(IF:30.927)

32.  Li J, Zhang JV, Cao YJ, Zhou JX, Liu WM, Fan XJ, Duan EK. Inhibition of the beta-catenin signaling pathway in blastocyst and uterus during the window of implantation in mice. BiolReprod. 2005, 72(3):700-706 (IF:3.583)

33. Mazerbourg S., Bouley D.M., Sudo S., Klein C.A., Zhang J.V., Kawamura K., Goodrich L.V., Rayburn H., Tessier-Lavigne M., Hsueh A.J.Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality,Molecular Endocrinology,2004,18(9):

2241-2254(IF3.347)

34. Zhang J, Cao YJ, Li FY, Li J, Yao LB, Duan EK. Effects of fibronectin, VEGF and angiostatin on the expression of MMPs through different signaling pathways in the JEG-3 cells. Am J ReprodImmunol. 2003,50(4):273-285(IF:2.088)

35. Zhang J, Zhao YG, Cao YJ, Sang QX, Duan EK. Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo. Mol Hum Reprod. 2003,9(3):143-149 (IF:3.067)

36. Cai L, Zhang J, Duan E. Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation. Cytokine. 2003,23(6):170-178(IF:2.183)

37. DAI Bojie, CAO Yujing, WANG Xichao, ZHOU Jiaxi, ZHANG Jian, CHEN Dayuan& DUAN Enkui *.Expression of LIF, VEGF, CD57 and CD68 after the transfer of rat embryos to mouse uteri. Chinese Science Bulletin.2003, 48(6 ):542-548 (IF:0.593)

38. ZHAO TianFu#, Zhang Jian#(共同一作), L I Jing, CAO YuJing, L I SuMin, ZHOU JiaXi, DUAN EnKui  Minimum effective dose and regulatory mechanism of angiostatin-inhibited embryo implantation in the mouse. ActaZoologicaSinica, 2003,49(3):332-338  (IF:0.873)

39.  ZHAO TianFu*, Zhang Jian*(共同一作), Li Jing, Cao Yujing, Li SUmin, Zhou Jiaxi, Li Fuyang, Yao Libo, DuanEnkui. Regulation Effects of Angiostatin on The Mouse Blastocysts. Progress in Biochemistry and Biophysics.2003,30 (5):778-783(IF:0.241)

40. Zhang J, Cao YJ, Zhao YG, Sang QX, Duan EK. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3. Mol Hum Reprod. 2002 8(7):659-666(IF:3.06)

41. Li Sumin, Cao Yujing, Zhang Jian, TianYongqiang, Zheng Xing &DuanEnkui*. Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice. Chinese Sci Bull.2002, 47 (24 ):2071-2074 (IF:0.593)

42. Zhang Jian, Cao Yujing , Liu Weimin, Zhao Bingshun, ZengGuoqing&DuanEnkui *. Expression of matrix metalloproteinase -28 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3, Chinese Sci Bull.2002, 47(9)732-736 (IF:0.593)

43.  Zhang Jian, TIE Guodong, CAO Yujing and DUAN Enkui* . Effect offibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst. Chinese Sci Bull.2001,46(15)1296-1299 (IF:0.593)

44. ZhangJian, DuanEnkui ,Uteroglobin: Structure and Function. Progress in Biochemistry and Biophysics.2001,28(5):627-630 (IF:0.593)

45. 张键,段恩奎. 空间生殖与发育生物学及组织工程研究展望. 《中华航空航天医学杂志》,2001年第12卷第3期,184-186页